| When | What | Who | Details |
|---|---|---|---|
| Sep. 19 | Journal club | Hakan Solak | Milind et al. 2024, Buffering and non-monotonic behavior of gene dosage response curves for human complex traits (medRxiv). |
| Sep. 26 | Journal club | Natanael Spisak | Schraiber et al. 2025, Estimation of demography and mutation rates from one million haploid genomes (AJHG). |
| Oct. 2 | Lab meeting | Richard Durbin | |
| Oct. 10 | Lab meeting | Milind Jagota and Anastasia Stolyarova |
A deep learning approach to differences in mutation spectra among primates. |
| Oct. 10 | Journal club | William Milligan | Kristmundsdottir et al. 2023, Sequence variants affecting the genome-wide rate of germline microsatellite mutations (Nature Comms.). |
| Oct. 31 | Lab meeting | Daria Bykova and Arjun Sai Krishnan |
Population genetics of Acropora millepora. |
| Oct. 31 | Journal club | Sool Lee | Ota et al. 2025, Causal modeling of gene effects from regulators to programs to traits: integration of genetic associations and Perturb-seq (bioRxiv). |
| Nov. 13 | Journal club | Matin Saeidi | Lawson et al. 2025, Somatic mutation and selection at population scale (Nature). |
| Nov. 14 | Lab meeting | Yanina Kuzminich | Age and sex dependency of genetic effects on low-density lipoprotein cholesterol in UK Biobank. |
| Nov. 21 | Journal club | Naima Okami | Ramirez-Lanzas et al. 2025, Tracking polygenic adaptation: phenotypic stasis after rapid adaptation in large populations of Drosophila (bioRxiv). |
| Dec. 5 | Lab meeting | Vanesa Getseva and Lin Poyraz |
Leveraging relatedness in genomic datasets to study variation in germline mutation rates. |
| Dec. 5 | Journal club | Julie Zhu | Wainschtein et al. 2025, Estimation and mapping of the missing heritability of human phenotypes (Nature). |
| Dec. 12 | Lab meeting | Naima Okami | The genetics of toxin resistance evolution: an experimental approach. |
| When | What | Who | Details |
|---|---|---|---|
| Mar. 3 | Lab meeting | Donate Weghorn | Dissecting germline and somatic mutational processes across space and time. |
| Apr. 28 | Lab meeting | Sou Tomimoto | The developmental and evolutionary trajectory of somatic mutations in long-lived plants. |
| May 9 | Lab meeting | Peter Andolfatto | The genetic basis of convergent color patterns in distantly related frogs. |
| June 13 | Lab meeting | Steph Blain | Identifying genomic contributors to survival in an avian hybrid zone. |
| June 20 | Lab meeting | Peter Andolfatto | Reanalysis of a massive Drosophila longevity experiment. |
| When | What | Who | Details |
|---|---|---|---|
| Oct. 18 | Lab meeting | Natanael Spisak | Inaccurate synthesis in response to DNA damage is a common source of mutation. |
| Nov. 1 | Lab meeting | Vanesa Getseva and Lin Poyraz |
A sibling study of parental mutation rates. |
| Nov. 8 | Lab meeting | Alex Pyron | Speciation genomics in salamanders. |
| Nov. 15 | Lab meeting | Augustine Kong | Some thoughts on factors that could bias parameter estimates in genome-wide association studies. |
| Dec. 3 | Lab meeting | Melissa Naugle | Genomic basis of heat tolerance traits in Acropora hyacinthus on the Great Barrier Reef. |
| Dec. 13 | Lab meeting | Anastasia Stolyarova | Evolution of mutation spectrum in primates. |
| When | What | Who | Details |
|---|---|---|---|
| Jan. 19 | Lab meeting | Georgii Bazykin | Towards understanding and forecasting evolution of pathogenic viruses. |
| Jan. 26 | Lab meeting | Ruth Epstein | Investigating recombination rate evolution during maize domestication. |
| Feb. 1 | Lab meeting | Lin Poyraz | Lab meeting | Anastasia Stolyarova |
| Feb. 15 | Lab meeting | Lino Ferreira | Polygenic scores enable the discovery of genetic interactions associated with human complex traits in the UK Biobank. | Journal club | Allen Dinh | Buffalo et al. 2023, A quantitative genetic model of background selection in humans. |
| Mar. 1 | Lab meeting | Yuki Haba | Origin and evolutionary history of Culex pipiens complex mosquitoes. |
| Mar. 15 | Lab meeting | Hannah Munby | Identifying long-lived balanced polymorphisms in humans. |
| Mar. 22 | Journal club | Jiarun Chen | Hoellinger et al. 2023, A theory of oligogenic adaptation of a quantitative trait. |
| Apr. 18 | Lab meeting | Guillaume Achaz | Weak genetic draft and the Lewontin’s paradox. |
| May 17 | Conference | New York Area Population Genetics Meeting | |
| May 24 | Lab meeting | Carla Hoge Arjun Sai Krishnan |
Population genomics of the stony coral Acropora millepora across the Great Barrier Reef | Journal club | Lin Poyraz | Schneemann et al. 2024, Fisher’s geometric model as a tool to study speciation. |
| May 31 | Lab meeting | Jiarun Chen | Polygenic adaptation under recurrent changes in environment. |
| June 7 | Lab meeting | Kip Lacy | Co-inheritance of crossover products maintains heterozygosity in a parthenogenetic ant. | Journal club | Flora Borne | Papkou et al. 2023, A rugged yet easily navigable fitness landscape. |
| June 14 | Lab meeting | Sylvia Durkin | Genetic and environmental determinants of adaptive phenotypes in tropical and temperate house mice. | Journal club | Carla Hoge | Hinch et al. 2023, Meiotic DNA breaks drive multifaceted mutagenesis in the human germ line. |
| June 21 | Lab meeting | Vanesa Getseva | A sibling study of parental mutation rates | Journal club | Natanael Spisak | Schraiber et al. 2024, Unifying approaches from statistical genetics and phylogenetics for mapping phenotypes in structured populations. |
| June 28 | Lab meeting | Matin Saeidi | Mutator alleles: from theoretical models to empirical evidence |
| When | What | Who | Details |
|---|---|---|---|
| Sept. 8 | Lab meeting | Angela Wei | The genetic underpinnings of variable penetrance and expressivity of pathogenic mutations in cardiometabolic traits. |
| Sept. 15 | Lab meeting | Hanbin Lee | Exposing the underlying randomness of genetic inference. |
| Journal club | Anastasia Stolyarova | Rodrigues et al. 2023, Shared evolutionary processes shape landscapes of genomic variation in the great apes. | |
| Sept. 22 | Journal club | Djivan Prentout | Gawra et al. 2023, Epigenetic variations are more substantial than genetic variations in rapid adaptation of oyster to Pacific oyster mortality syndrome. |
| Sept. 29 | Lab meeting | Anastasia Stolyarova | Mutation bias in driver genes reveals distribution of effects of oncogenic mutations. |
| Oct. 6 | Journal club | Natanael Spisak | Anderson et al. 2022, Strand-resolved mutagenicity of DNA damage and repair. |
| Oct. 13 | Lab meeting | Flora Borne | Epistasis among clustered lineage-specific mutations in Drosophila trio. |
| Oct. 19 | Lab meeting | Marion Talbi | Rapid evolution of recombination rates in cichlid fishes. |
| Milan Malinsky | Generating recombination maps from bulk sperm Hi-C. | ||
| Oct. 27 | Journal club | Hannah Munby | Bajpai et al. 2023, A genome-wide genetic screen uncovers determinants of human pigmentation. |
| Nov. 6 | Lab meeting | Bárbara Mota | A Tale of Two Cities: how imputation can expand ancient DNA studies and what ancient genomics reveals about the Rapanui. |
| Nov. 10 | Lab meeting | Ana Pinharanda | Cis-regulatory evolution of Wnt-family genes underlies morphological evolution in the domesticated silkworm. |
| Journal club | Arjun Sai Krishnan | Vollmer et al. 2023, Genomic signatures of disease resistance in endangered staghorn corals. | |
| Nov. 17 | Journal club | Marc de Manuel | Lu et al. 2023, Universal DNA methylation age across mammalian tissues. |
| Dec. 1 | Lab meeting | Djivan Prentout | Meiotic recombination in a species lacking PRDM9 (zebra finch). |
| Journal club | Vanesa Getseva | Liu et al. 2022, Somatic mutational profiles and germline polygenic risk scores in human cancer. | |
| Dec. 4 | Lab meeting | Núria Hermosilla | Population genomics and evolution of amazonian primates: from uakaris to spider monkeys. |
| Dec. 7 | Lab meeting | Sam Trejo | Disentangling race and ancestry for non-academic audiences. |
| When | What | Who | Details |
|---|---|---|---|
| Jan. 13 | Lab meeting | Minyoung Wyman | Transcription-coupled repair in the germline. |
| Journal club | Hannah Munby | Schield et al. 2022, The roles of balancing selection and recombination in the evolution of rattlesnake venom (Nat Ecol Evol). | |
| Feb. 10 | Lab meeting | Vanesa Getseva | An approach to identify mutator alleles in humans. |
| Journal club | Akanksha Bhat | Muralidhar et al. 2022, Assortative mating enhances postzygotic barriers to gene flow via ancestry bundling (PNAS). | |
| Mar. 3 | Lab meeting | Natanael Spisak | Modeling helps to identify key parameters of human mutagenesis. |
| Carla Hoge | A tug of war between PRDM9 and promoter-like features revealed by the study of a non-mammalian vertebrate. | ||
| Journal club | Andrés Bendesky and Magnus Nordborg |
Dutrow et al. 2022, Domestic dog lineages reveal genetic drivers of behavioral diversification (Cell). | |
| Mar. 13 | Lab meeting | Simon Myers | |
| Apr. 7 | Journal club | Natanael Spisak | Jumper et al. 2021, Highly accurate protein structure prediction with AlphaFold (Nature). |
| Apr. 14 | Lab meeting | Robin Burns | Cycles of satellite and transposon evolution in arabidopsis centromeres. |
| Apr. 21 | Lab meeting | Marc de Manuel and Natanael Spisak |
Mechanisms behind mutational signatures. |
| Apr. 28 | Lab meeting | Djivan Prentout | Recombination in zebra finch. |
| May 5 | Lab meeting | Aleksandra Kornienko | Extensive natural variation and silencing of lncRNAs in Arabidopsis thaliana. |
| May 8 | Lab meeting | Joyce Wang | The poor portability of polygenic scores is only partially attributable to genetic ancestry. |
| May 12 | Thesis defense | Will Milligan | |
| May 19 | Lab meeting | Vladimir Seplyarskiy | Evolution of mutational processes in mammals. |
| July 6 | Lab meeting | Hannah Munby | Investigating long-lived balancing selection using shared variation between human and chimpanzee. |
| When | What | Who | Details |
|---|---|---|---|
| Sept. 30 | Journal club | Young Mi Kwon | Tilk et al. 2022, Most cancers carry a substantial deleterious load due to Hill-Robertson interference (eLife). |
| Oct. 7 | Lab meeting | Magnus Nordborg | Methylation madness. |
| Oct. 21 | Lab meeting | Yige Zhao | Predicting functional and fitness effect of missense variants. |
| Nov. 4 | Lab meeting | Magnus Nordborg | Methylation madness continued. |
| Journal club | Minyoung Wyman | Cosby et al. 2021, Recurrent evolution of vertebrate transcription factors by transposase capture (Science). | |
| Nov. 11 | Journal club | Carla Hoge | Wang et al. 2022, Comparative genome anatomy reveals evolutionary insights into a unique amphitriploid fish (Nat Ecol Evol). |
| Nov. 14 | Lab meeting | Jeremy Berg | |
| Nov. 18 | Journal club | Marc de Manuel | Kaplanis et al. 2022, Genetic and chemotherapeutic influences on germline hypermutation (Nature). |
| Dec. 2 | Lab meeting | Meret Arter | |
| Journal club | Vanesa Getseva | Mbatchou et al. 2021, Computationally efficient whole-genome regression for quantitative and binary traits (Nature Genetics). | |
| Dec. 9 | Lab meeting | Manyuan Long | The Origination of Genes from Scratch under Sexual Conflict. |
| Journal club | Magnus Nordborg | Brovkina et al. 2022, A common genomic architecture for interacting with the external world (bioRxiv). | |
| Dec. 16 | Lab meeting | David Stern | |
| Lab meeting | Joy Bergelson and Magnus Nordborg |
Field GWAS and experimental evolution experiments reveal genetic tradeoffs in response to temporally and spatially variable selection |
| When | What | Who | Details |
|---|---|---|---|
| January 28th | Lab Meeting | Pei-Yin Shih | Population genetics of fighting fish |
| February 18th | Lab Meeting | Margaret Antonio | Using ancient DNA to explore recent human population structure. |
| Journal Club | Hannah Munby | Ebel et al. 2022, Revisiting the malaria hypothesis: accounting for polygenicity and pleiotropy Trends in Parasitology. |
|
| March 4th | Lab Meeting | Alison Barton | Investigating the contribution of rare coding variants to phenotypes in UK Biobank. |
| Journal Club | Carla Hoge | Marcovitz et al. 2019, A functional enrichment test for molecular convergent evolution finds a clear protein-coding signal in echolocating bats and whales PNAS. |
|
| March 11th | Lab Meeting | Jeff Spence | Simulation-based machine learning in population genetics as approximate Bayesian inference |
| Journal Club | Marc de Manuel | Rockweiler et al. 2022, The origins and functional effects of postzygotic mutations throughout the human lifespan bioRxiv. |
|
| March 18th | Lab Meeting | Carla Hoge | Recombination patterns in cornsnakes suggest a tug of war between PRDM9 and promoter-like features |
| Journal Club | Djivan Prentout | Lenormand and Roze 2022, Y recombination arrest and degeneration in the absence of sexual dimorphism Science and Jay et al. 2022 Modeling the stepwise extension of recombination suppression on sex chromosomes and other supergenes through deleterious mutation sheltering bioRxiv. |
|
| March 25th | Lab Meeting | Minyoung Wyman | T-asymmetry in the human germline |
| April 29th | Journal Club | Will Milligan | Genetics of participation |
| May 6th | Lab Meeting | Carrie Zhu | Amplification is the primary mode of gene-by-sex interaction in complex human traits |
| May 11th | Lab Meeting | Will Milligan | Conditions for large effect fixations under polygenic adaptation |
| May 13th | Lab Meeting | Djivan Prentour | TBD |
| June 3rd | Lab Meeting | Carla Hoge | TBD |
| Lab Meeting | Will Milligan | Practice PEQG talk | |
| June 13th | Lab Meeting | Jiarun Chen | Polygenic Adaptation under Recurrent Changes in Environment |
| June 17th | Journal Club | Molly Przeworski | Okbay et al. 2022, Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals Nature genetics. |
| July 13th | Lab Meeting | Marc de Manuel | TBD |
| July 20th | Lab Meeting | Ana Pinharanda | TBD |
| July 27th | Lab Meeting | Flora Borne | TBD |
Schedule for Fall 2021:
| When | What | Who | Details |
|---|---|---|---|
| September 17th | Lab Meeting (1:30 PM – 2:45 PM) | Will Milligan | Polygenic adaptation with low polygenicity |
| Journal Club | Felix Wu | LeCun et al. 2015, Deep Learning Nature. | |
| September 24th | Lab Meeting | Felix Wu and Marc de Manuel | The evolution of sex bias in mutation across amniotes |
| Journal Club | TBD | Deep Learning part 2 | |
| October 1st | Lab Meeting | Michael Goldberg | Variation in germline de novo mutagenesis in human families |
| Journal Club | Will Milligan | Cagan et al. 2021, Somatic mutation rates scale with lifespan across mammals BioRxiv. |
|
| October 8th | Journal Club | Hannah Munby | Ferris et al. 2021, The genomics of rapid climatic adaptation and parallel evolution in North American house mice PLOS Genetics. |
| October 22st | Journal Club | Ziqing Pan | Dukler et al. 2021, Extreme purifying selection against point mutations in the human genome BioRxiv. |
| October 29th | Journal Club | Group | Deep learning part 2 |
| Journal Club | Minyoung Wyman | Svensson et al. 2021, Correlational selection in the age of genomics Nature Ecology & Evolution. |
|
| November 5th @ 12pm | Lab Meeting | Ipsita Agarwal | Fitness effects of new mutations |
| Journal Club | Group | Deep learning part 3 | |
| November 19th | Lab Meeting | Natanael Spisak | Insights into affinity maturation from B cell repertoire sequencing |
| Journal Club | Hannah Munby | Ferris et al. 2021, The genomics of rapid climatic adaptation and parallel evolution in North American house mice PLOS Genetics. |
|
| December 3rd | Journal Club | Marc de Manuel Montero | Murat et al. 2021, The molecular evolution of spermatogenesis across mammal BioRxiv. |
| December 10th | Lab Meeting | Nicholas Lillis | TBD |
| Journal Club | Jiarun Chen | Cortes et al. 2020, Identifying cross-disease components of genetic risk across hospital data in the UK Biobank Nature Genetics. |
| When | What | Who | Details |
|---|---|---|---|
| January 8th | Lab Meeting | Ipsita Agarwal | Mutation saturation in current samples |
| Journal club | Marc de Manuel | Baur & Berger 2020, Experimental evidence for effects of sexual selection on condition-dependent mutation rates Nature Ecology & Evolution | |
| January 15th | Lab Meeting | Eric Turkheimer | Are SNPs related to complex human behavior causal? Does it matter? |
| Journal club | Eric Turkheimer | Fisher 1919, The causes of human variability Eugenics Review | |
| January 29th | Lab Meeting | Felix Wu and Marc de Manuel | Estimating male mutation bias across mammals |
| February 5th | Journal club | Felix Wu | Bhutani et al. 2021, Widespread haploid-biased gene expression enables sperm-level natural selection/a> Science |
| February 12th | Journal club | Ana Pinharanda | Kennedy and Reade 2017, Why does drug resistance readily evolve but vaccine resistance does not? Proceedings of the Royal Society B |
| March 5th | Lab Meeting | Hakhamanesh Mostafavi | |
| March 12th | Lab Meeting | Vince Buffalo | Why do species get a thin slice of π? Revisiting Lewontin’s Paradox of Variation. |
| March 19th | Lab Meeting | Arslan Zaidi | |
| March 26th | Lab Meeting | Molly Schumer | The genetic architecture and evolutionary origin of a lethal hybrid incompatibility. |
| Journal Club | Zach Fuller | Jones et al. 2020, Convergent evolution of seasonal camouflage in response to reduced snow cover across the snowshoe hare range Evolution | |
| April 2nd | Lab Meeting | Ben Strober | Diverse transcriptomic signatures identify functional rare genetic variation. |
| Journal Club | Will Milligan | Strogatz, Exploring complex networks Nature | |
| April 9th | Lab Meeting | Thomas Sasani | A wild-derived antimutator drives germline mutation spectrum differences in a genetically diverse murine family. |
| April 15th @ 9:30 AM | Lab Meeting | Flora Borne | Evolution of the glue produced by Drosophila larvae. |
| April 16th | Journal Club | Anna Yoney | Bizzotto et al. 2021, Landmarks of human embryonic development |
| April 23rd | Lab Meeting | Chris Large | |
| Journal Club | Ana Pinharanda | Gokhman et al. 2021, Human–chimpanzee fused cells reveal cis-regulatory divergence underlying skeletal evolution Nature Genetics | |
| May 13th @ 10:30 AM (EDT) | Lab Meeting | Djivan Prentout | Plant genera Cannabis and Humulus share the same pair of well-differentiated sex chromosomes. |
| May 14th | Journal Club | Marc de Manuel Montero | Abascal et al. 2021, Somatic mutation landscapes at single-molecule resolution nature. |
| May 21st | Lab Meeting | Ellen Leffler | Host-parasite genetic interactions in malaria |
| May 28th 10:30 AM -12 PM | Lab Meeting | Ziyue Gao | |
| June 11th | Journal Club | Carla Hoge | Pratt et al. 2021, Germline DNA replication shapes the recombination landscape in mammals BioRxiv. |
| Journal Club | Daniel Hooper | Wang et al. 2021, Transcriptional regulatory divergence underpinning species-specific learned vocalization in songbirds PLOS Biology. | |
| July 16th | Lab Meeting | Florian Labourel | A mechanistic view of the Evolution of diversity. |